Switch #:
SWTI000401
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y368 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.

Participants:
(1) Erythropoietin receptor (EPOR)
(2) Signal transducer and activator of transcription 5B (STAT5B)

Interactions
Interaction #1 EPOR - STAT5B

Interfaces
(1) ELM:LIG_SH2_III motif (360GSEHAQDTYLVLDKWLL376) in Erythropoietin receptor (EPOR)
(2) SH2 domain (593-670) in Signal transducer and activator of transcription 5B (STAT5B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y368 on Erythropoietin receptor (EPOR)) of the Erythropoietin receptor (EPOR) LIG_SH2_III motif - Signal transducer and activator of transcription 5B (STAT5B) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y368 : Tyrosine-protein kinase JAK2 (JAK2), Tyrosine-protein kinase Lyn (LYN).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane


Switch pathways
Inferred: Jak-STAT signaling pathway
References

(1) Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain.
Drachman et al. Proc. Natl. Acad. Sci. U.S.A. (1997)




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