Switch #:
SWTI000402
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y426 in the SH2-binding motif of Erythropoietin receptor (EPOR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.

Participants:
(1) Erythropoietin receptor (EPOR)
(2) Signal transducer and activator of transcription 5B (STAT5B)

Interactions
Interaction #1 EPOR - STAT5B

Interfaces
(1) ELM:LIG_SH2_III motif (418GASAASFEYTILDPSSQ434) in Erythropoietin receptor (EPOR)
(2) SH2 domain (593-670) in Signal transducer and activator of transcription 5B (STAT5B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y426 on Erythropoietin receptor (EPOR)) of the Erythropoietin receptor (EPOR) LIG_SH2_III motif - Signal transducer and activator of transcription 5B (STAT5B) SH2 domain interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane


Switch pathways
Inferred: Jak-STAT signaling pathway
References

(1) A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.
Barber et al. Blood (2001)




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