Switch #:
SWTI000400
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y481 in the SH2-binding motif of Interferon alpha/beta receptor 1 (IFNAR1) induces binding to the Non-receptor tyrosine-protein kinase TYK2 (TYK2) protein.

Participants:
(1) Interferon alpha/beta receptor 1 (IFNAR1)
(2) Non-receptor tyrosine-protein kinase TYK2 (TYK2)

Interactions
Interaction #1 IFNAR1 - TYK2

Interfaces
(1) ELM:LIG_SH2_IE motif (473KPSSSIDEYFSEQPLKN489) in Interferon alpha/beta receptor 1 (IFNAR1)
(2) Non-receptor tyrosine-protein kinase TYK2 (TYK2)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y481 on Interferon alpha/beta receptor 1 (IFNAR1)) of the Interferon alpha/beta receptor 1 (IFNAR1) LIG_SH2_IE motif - Non-receptor tyrosine-protein kinase TYK2 (TYK2) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y481 : Non-receptor tyrosine-protein kinase TYK2 (TYK2).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane


Switch pathways
Inferred: Jak-STAT signaling pathway, Osteoclast differentiation
References

(1) Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
Colamonici et al. Mol. Cell. Biol. (1994)




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