Description: T-cell surface antigen CD2 (CD2) uses overlapping motifs to bind to CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) and Fyn, which makes their interactions mutually exclusive. Since CD2BP2 and Tyrosine-protein kinase Fyn (FYN) reside in different subcellular locations, the specificity of CD2 for the two competitors is switched by changing its cellular localization, from non-raft membranes to lipid raft membranes.
Participants: (1) T-cell surface antigen CD2 (CD2) (2) CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) (3) Tyrosine-protein kinase Fyn (FYN)
(1) Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.Freund et al. EMBO J. (2002)
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