Description: Cyclin-dependent kinase inhibitor 1 (CDKN1A) (p21) and the M-phase inducer phosphatase 1 (CDC25A) bind the same site on Cyclin proteins (e.g. G1/S-specific cyclin-E1 (CCNE1)), making their interactions mutually exclusive.
Participants: (1) Cyclin-dependent kinase inhibitor 1 (CDKN1A) (2) G1/S-specific cyclin-E1 (CCNE1) (3) M-phase inducer phosphatase 1 (CDC25A)
(1) p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases.Saha et al. Mol. Cell. Biol. (1997)
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