Switch #:
SWTI000160
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S349 and S353 in the TrCP1-binding motif of Prolactin receptor (PRLR) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Prolactin receptor (PRLR)
(2) F-box/WD repeat-containing protein 11 (FBXW11)

Interactions
Interaction #1 PRLR - FBXW11

Interfaces
(1) DEG_SCF_TRCP1_1 motif (348DSGRGS353) in Prolactin receptor (PRLR)
(2) WD domain, G-beta repeat (232-266) and (270-306) and (310-346) and (353-389) and (393-429) and (433-469) and (482-518) in F-box/WD repeat-containing protein 11 (FBXW11)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S349 and S353 on Prolactin receptor (PRLR)) of the Prolactin receptor (PRLR) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 11 (FBXW11) WD domain, G-beta repeat interaction

Context
Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
References

(1) Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase.
Li et al. Mol. Cell. Biol. (2004)




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