Switch #:
SWTI000159
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S52 and S56 in the TrCP1-binding motif of Protein Vpu (vpu) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Protein Vpu (vpu)
(2) F-box/WD repeat-containing protein 1A (BTRC)

Interactions
Interaction #1 vpu - BTRC

Interfaces
(1) DEG_SCF_TRCP1_1 motif (51DSGNES56) in Protein Vpu (vpu)
(2) WD domain, G-beta repeat (297-329) and (333-369) and (373-409) and (416-452) and (456-492) and (496-532) and (545-581) in F-box/WD repeat-containing protein 1A (BTRC)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S52 and S56 on Protein Vpu (vpu)) of the Protein Vpu (vpu) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 1A (BTRC) WD domain, G-beta repeat interaction

Context
Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
Inferred: cytosol
References

(1) HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates.
Besnard-Guerin et al. J. Biol. Chem. (2004)




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