Description: Dual phosphorylation of S219 and S224 in the TrCP1-binding motif of Cyclic AMP-dependent transcription factor ATF-4 (ATF4) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Participants: (1) Cyclic AMP-dependent transcription factor ATF-4 (ATF4) (2) F-box/WD repeat-containing protein 1A (BTRC)
(1) ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.Lassot et al. Mol. Cell. Biol. (2001)
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