Description: Dual phosphorylation of S157 and S161 in the TrCP1-binding motif of NF-kappa-B inhibitor epsilon (NFKBIE) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Participants: (1) NF-kappa-B inhibitor epsilon (NFKBIE) (2) F-box/WD repeat-containing protein 1A (BTRC)
(1) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.Shirane et al. J. Biol. Chem. (1999) (2) I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.Whiteside et al. EMBO J. (1997)
