Switch #:
SWTI000156
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S486 in the PIF pocket-binding motif of Serine/threonine-protein kinase Sgk3 (Sgk3) induces intramolecular binding and kinase cis-activation.

Participants:
(1) Serine/threonine-protein kinase Sgk3 (Sgk3)

Interactions
Interaction #1 Sgk3 - Sgk3(intramolecular)
intramolecular
Interfaces
(1) DOC_AGCK_PIF_1 motif (482FVGFSY487) in Serine/threonine-protein kinase Sgk3 (Sgk3)
(2) Protein kinase domain (162-419) in Serine/threonine-protein kinase Sgk3 (Sgk3)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S486 on Serine/threonine-protein kinase Sgk3 (Sgk3)) of the Serine/threonine-protein kinase Sgk3 (Sgk3) DOC_AGCK_PIF_1 motif - Serine/threonine-protein kinase Sgk3 (Sgk3) Protein kinase domain interaction

Context
References

(1) Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner.
Nilsen et al. J. Biol. Chem. (2004)




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