Switch #:
SWTI000158
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Dual phosphorylation of S211 and S215 in the TrCP1-binding motif of Latent membrane protein 1 (LMP1) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Participants:
(1) Latent membrane protein 1 (LMP1)
(2) F-box/WD repeat-containing protein 11 (FBXW11)

Interactions
Interaction #1 LMP1 - FBXW11

Interfaces
(1) DEG_SCF_TRCP1_1 motif (210DSGHES215) in Latent membrane protein 1 (LMP1)
(2) WD domain, G-beta repeat (232-266) and (270-306) and (310-346) and (353-389) and (393-429) and (433-469) and (482-518) in F-box/WD repeat-containing protein 11 (FBXW11)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S211 and S215 on Latent membrane protein 1 (LMP1)) of the Latent membrane protein 1 (LMP1) DEG_SCF_TRCP1_1 motif - F-box/WD repeat-containing protein 11 (FBXW11) WD domain, G-beta repeat interaction

Context
Switch localisation
ELM curated: nucleoplasm, nucleus, Chromosome, cytosol
References

(1) Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.
Tang et al. J. Biol. Chem. (2003)




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