Switch #:
SWTI000126
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T305 in the FHA-binding motif of RNA-binding protein PIN4 (PIN4) induces binding to the Serine/threonine-protein kinase RAD53 (RAD53) protein.

Participants:
(1) RNA-binding protein PIN4 (PIN4)
(2) Serine/threonine-protein kinase RAD53 (RAD53)

Interactions
Interaction #1 PIN4 - RAD53

Interfaces
(1) LIG_FHA_1 motif (303PDTLEIY309) in RNA-binding protein PIN4 (PIN4)
(2) FHA domain (66-133) in Serine/threonine-protein kinase RAD53 (RAD53)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T305 on RNA-binding protein PIN4 (PIN4)) of the RNA-binding protein PIN4 (PIN4) LIG_FHA_1 motif - Serine/threonine-protein kinase RAD53 (RAD53) FHA domain interaction

Context
Switch localisation
ELM curated: nucleus
References

(1) Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.
Pike et al. Mol. Cell. Biol. (2004)




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