Switch #:
SWTI000127
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T868 in the FHA-binding motif of Receptor protein kinase CLAVATA1 (CLV1) induces binding to the Protein phosphatase 2C 70 (KAPP) protein.

Participants:
(1) Receptor protein kinase CLAVATA1 (CLV1)
(2) Protein phosphatase 2C 70 (KAPP)

Interactions
Interaction #1 CLV1 - KAPP

Interfaces
(1) LIG_FHA_1 motif (866AYTLKVD872) in Receptor protein kinase CLAVATA1 (CLV1)
(2) FHA domain (208-284) in Protein phosphatase 2C 70 (KAPP)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T868 on Receptor protein kinase CLAVATA1 (CLV1)) of the Receptor protein kinase CLAVATA1 (CLV1) LIG_FHA_1 motif - Protein phosphatase 2C 70 (KAPP) FHA domain interaction

Context
References

(1) PhosphoThr peptide binding globally rigidifies much of the FHA domain from Arabidopsis receptor kinase-associated protein phosphatase.
Ding et al. Biochemistry (2005)




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