Switch #:
SWTI000009
Switch type:
Uncategorised
Switch subtype:
Uncategorised

Description:
Phosphorylation of T156 in AP-2 complex subunit mu (AP2M1) by AP2-associated protein kinase 1 (AAK1) upon clathrin recruitment strengthens the interaction between AP-2 complex subunit mu (AP2M1) and cargo proteins.

Participants:
(1) Lysosomal acid phosphatase (ACP2)
(2) AP-2 complex subunit mu (AP2M1)

Interactions
Interaction #1 ACP2 - AP2M1

Interfaces
(1) TRG_ENDOCYTIC_2 motif (413YRHV416) in Lysosomal acid phosphatase (ACP2)
(2) Adaptor complexes medium subunit family (159-435) in AP-2 complex subunit mu (AP2M1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T156 on AP-2 complex subunit mu (AP2M1)) of the Lysosomal acid phosphatase (ACP2) TRG_ENDOCYTIC_2 motif - AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T156: AP2-associated protein kinase 1 (AAK1)

Context
Switch localisation
ELM curated: cytosol, clathrin-coated endocytic vesicle, plasma membrane
Inferred: lysosomal membrane
References

(1) Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals.
Ricotta et al. J. Cell Biol. (2002)




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