Switch #:
SWTI000008
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S216 in a 14-3-3-binding motif of M-phase inducer phosphatase 3 (CDC25C) by Serine/threonine-protein kinase Chk1 (CHEK1) induces binding to 14-3-3 protein beta/alpha (YWHAB), which negatively regulates M-phase inducer phosphatase 3 (CDC25C).

Participants:
(1) M-phase inducer phosphatase 3 (CDC25C)
(2) 14-3-3 protein beta/alpha (YWHAB)

Interactions
Context
References

(1) Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
Peng et al. Science (1997)




Loading visualisation