Description: Phosphorylation of Y530 in the SH2-binding motif of Proto-oncogene tyrosine-protein kinase Src (SRC) induces an intramolecular interaction with the SH2 domain of Proto-oncogene tyrosine-protein kinase Src (SRC) resulting in inhibition of its activity and preventing intermolecular interactions of its SH2 domain.
Participants: (1) Proto-oncogene tyrosine-protein kinase Src (SRC)
(1) Kinome signaling through regulated protein-protein interactions in normal and cancer cells.Pawson et al. Curr. Opin. Cell Biol. (2009)
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