Switch #:
SWTI000707
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the Sumoylation interacting motif (SIM) of Protein PML (PML), abrogating binding to Small ubiquitin-related modifier 1 (SUMO1) in Isoform TRIM19epsilon of Protein PML (PML). Isoforms lacking the SIM were resistant to As2O3-induced PML degradation.

Participants:
(1) Protein PML (PML)
(2) Small ubiquitin-related modifier 1 (SUMO1)

Interactions
Interaction #1 PML - SUMO1

Interfaces
(1) LIG_SUMO_SBM_1 motif (556VVVISSSEDSD566) in Protein PML (PML)
(2) Ubiquitin-2 like Rad60 SUMO-like (22-92) in Small ubiquitin-related modifier 1 (SUMO1)

Interaction Regulation
Alternative splicing Abrogation of the Protein PML (PML) LIG_SUMO_SBM_1 motif - Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin-2 like Rad60 SUMO-like interaction

Context
Switch localisation
Inferred: cytoplasm, nuclear membrane
References

(1) Requirement of PML SUMO Interacting Motif for RNF4- or Arsenic Trioxide-Induced Degradation of Nuclear PML Isoforms.
Maroui et al. PLoS ONE (2012)




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