Description: Acetylation of K37 in the SUMO1 inhibits binding to the Small ubiquitin-related modifier 1 (SUMO1) protein see switch details. SUMO-modified forms of Protein PML (PML) are essential for the recruitment of DAXX to PML nuclear bodies. The acetylated versions of SUMO1/2 failed to trigger recruitment of DAXX into the nuclear bodies. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.
Participants: (1) Death domain-associated protein 6 (DAXX) (2) Small ubiquitin-related modifier 1 (SUMO1)
(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.Ullmann et al. Mol. Cell (2012)
