Switch #:
SWTI000665
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Acetylation of K37 in Small ubiquitin-related modifier 1 (SUMO1) inhibits binding to E3 SUMO-protein ligase PIAS2 (PIAS2). The acetylation counters SUMO-SIM-dependent transcriptional repression processes. Acetylation is countered by Histone deacetylase family, HD type 1 subfamily.

Participants:
(1) E3 SUMO-protein ligase PIAS2 (PIAS2)
(2) Small ubiquitin-related modifier 1 (SUMO1)

Interactions
Interaction #1 PIAS2 - SUMO1

Interfaces
(1) LIG_SUMO_SBM_1 motif (467VDVID471) in E3 SUMO-protein ligase PIAS2 (PIAS2)
(2) Ubiquitin-2 like Rad60 SUMO-like (22-92) in Small ubiquitin-related modifier 1 (SUMO1)

Interaction Regulation
PTM-dependent Induction (Acetylation of K37 on Small ubiquitin-related modifier 1 (SUMO1)) of the E3 SUMO-protein ligase PIAS2 (PIAS2) LIG_SUMO_SBM_1 motif - Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin-2 like Rad60 SUMO-like interaction

Context
Switch localisation
Inferred: nuclear speck
References

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)




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