Switch #:
SWTI000666
Switch type:
Uncategorised
Switch subtype:
Uncategorised

Description:
Sumoylation of K160 induces binding to the Protein PML (PML) protein. SUMO-modified forms of PML are essential for the recruitment of Death domain-associated protein 6 (DAXX) to PML nuclear bodies.

Participants:
(1) Protein PML (PML)
(2) SUMO-conjugating enzyme UBC9 (UBE2I)
(3) Death domain-associated protein 6 (DAXX)
(4) Small ubiquitin-related modifier 2 (SUMO2)

Interactions
This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
1Interaction #1 PML - UBE2I

Interfaces
(1) MOD_SUMO motif (159LKHE162) in Protein PML (PML)
(2) Ubiquitin-conjugating enzyme (8-152) in SUMO-conjugating enzyme UBC9 (UBE2I)

Interaction Regulation
PTM-dependent Induction (MOD:01149 at K160 on Protein PML (PML)) of the Protein PML (PML) MOD_SUMO motif - SUMO-conjugating enzyme UBC9 (UBE2I) Ubiquitin-conjugating enzyme interaction

Context
References

(1) An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks.
Ullmann et al. Mol. Cell (2012)




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