Description: Alternative splicing removes the PDZ-binding motif of Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4), abrogating binding to Sorting nexin-27 (Snx27). Snx27 is responsible for targeting of the Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) to early endosomes.
Participants: (1) Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) (2) Sorting nexin-27 (Snx27)
(1) New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.Joubert et al. J. Cell. Sci. (2004)
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