Switch #:
SWTI000498
Switch type:
Binary
Switch subtype:
Pre-translational

Description:
Alternative splicing removes the PDZ-binding motif of Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4), abrogating binding to Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1). Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4) interacts specifically with a protein complex including Slc9a3r1 and Ezrin (Ezr) that might participate in its targeting to specialised subcellular regions, such as microvilli.

Participants:
(1) Isoform 5-HT4(A) of 5-hydroxytryptamine receptor 4 (Htr4)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (Slc9a3r1)

Interactions
Context
References

(1) New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.
Joubert et al. J. Cell. Sci. (2004)




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