Switch #: SWTI000480

Switch type: Binary

Switch subtype: Pre-translational

Description:
Alternative splicing removes the PI(4,5)P2-binding motif of Isoform BIN1 of Myc box-dependent-interacting protein 1 (BIN1), abrogating binding to 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. Splice-specific motifs in Isoform BIN1 of Myc box-dependent-interacting protein 1 (BIN1) engage in an intra-molecular interaction with its own SH3 domain. Auto-inhibition is relieved at the plasma membrane when an overlapping lipid-binding motif outcompetes the SH3-binding motif. This means that the SH3 domain is only available for inter-molecular interactions at the plasma membrane.

Participants:
(1) Isoform BIN1 of Myc box-dependent-interacting protein 1 (BIN1)
(2) 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

(1) Regulation of Bin1 SH3 domain binding by phosphoinositides.
Kojima et al. EMBO J. (2004)