Description: Alternative splicing removes the NRBOX motif of Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1), abrogating binding to Estrogen receptor (ESR1). Unlike splice variants without the NRBOX motif, TrxR1b (also known as Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1)) is identified within the nucleus. TrxR1b enhanced the transcriptional activity of the estrogen receptors ESR1 and ESR2, possibly by providing a reduced environment in the immediate vicinity of the ERs.
Participants: (1) Isoform TXNRD1_v2 of Thioredoxin reductase 1, cytoplasmic (TXNRD1) (2) Estrogen receptor (ESR1)
(1) An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.Damdimopoulos et al. J. Biol. Chem. (2004)
