Switches.ELM

Switch #:

SWTI000439

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y813 in the SH2-binding motif of Tyrosine-protein kinase JAK2 (Jak2) induces binding to the Signal transducer and activator of transcription 5B (Stat5b) protein.

Participants:
(1) Tyrosine-protein kinase JAK2 (Jak2)
(2) Signal transducer and activator of transcription 5B (Stat5b)

Interactions

Interaction #1 Jak2 - Stat5b

Interfaces
(1) ELM:LIG_SH2_III motif (₈₀₄DLNSLFTPDYELLTEND₈₂₀) in Tyrosine-protein kinase JAK2 (Jak2)
(2) SH2 domain_(593-670) in Signal transducer and activator of transcription 5B (Stat5b)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₈₁₃ on Tyrosine-protein kinase JAK2 (Jak2)) of the Tyrosine-protein kinase JAK2 (Jak2) LIG_SH2_III motif - Signal transducer and activator of transcription 5B (Stat5b) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y₈₁₃ : Tyrosine-protein kinase JAK2 (JAK2), Tyrosine-protein kinase JAK2 (Jak2).

Context

Switch localisation

References

(1) Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta.
Kurzer et al. Mol. Cell. Biol. (2004)