Switch #:
SWTI000440
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y362 in the SH2-binding motif of Breast cancer anti-estrogen resistance protein 1 (BCAR1) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) Breast cancer anti-estrogen resistance protein 1 (BCAR1)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 BCAR1 - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (358AEDVYDVPPPA368) in Breast cancer anti-estrogen resistance protein 1 (BCAR1)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y362 on Breast cancer anti-estrogen resistance protein 1 (BCAR1)) of the Breast cancer anti-estrogen resistance protein 1 (BCAR1) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction

Additional Information
Affinity : 0.35 µM
Context
Switch localisation
Inferred: cytosol


Switch pathways
Inferred: Chemokine signaling pathway, Regulation of actin cytoskeleton, Focal adhesion
References

(1) SH2 domains recognize contextual peptide sequence information to determine selectivity.
Liu et al. Mol. Cell Proteomics (2010)




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