Description: Phosphorylation of Y427 in the SH2-binding motif of SHC-transforming protein 1 (SHC1) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.
Participants: (1) SHC-transforming protein 1 (SHC1) (2) Growth factor receptor-bound protein 2 (GRB2)
(1) Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide.Ogura et al. J. Mol. Biol. (1999)
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