Switch #:
SWTI000417
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y602 in the SH2-binding motif of Ephrin type-A receptor 3 (EPHA3) induces binding to the Cytoplasmic protein NCK1 (NCK1) protein.

Participants:
(1) Ephrin type-A receptor 3 (EPHA3)
(2) Cytoplasmic protein NCK1 (NCK1)

Interactions
Interaction #1 EPHA3 - NCK1

Interfaces
(1) ELM:LIG_SH2_IA motif (597VDPHTYEDPT606) in Ephrin type-A receptor 3 (EPHA3)
(2) SH2 domain (282-356) in Cytoplasmic protein NCK1 (NCK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y602 on Ephrin type-A receptor 3 (EPHA3)) of the Ephrin type-A receptor 3 (EPHA3) LIG_SH2_IA motif - Cytoplasmic protein NCK1 (NCK1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y602 : Ephrin type-A receptor 3 (EPHA3).

Context

Switch pathways
Inferred: Axon guidance
References

(1) Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1.
Hu et al. Biochemistry (2009)




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