Description: Phosphorylation of Y595 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) protein.
Participants: (1) Growth hormone receptor (GHR) (2) Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
(1) Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.Stofega et al. Mol. Endocrinol. (2000)
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