Switch #:
SWTI000391
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y436 in the SH2-binding motif of Growth hormone receptor (GHR) induces binding to the Signal transducer and activator of transcription 5B (STAT5B) protein.

Participants:
(1) Growth hormone receptor (GHR)
(2) Signal transducer and activator of transcription 5B (STAT5B)

Interactions
Interaction #1 GHR - STAT5B

Interfaces
(1) ELM:LIG_SH2_III motif (428QKNQNNSPYHDACPATQ444) in Growth hormone receptor (GHR)
(2) SH2 domain (593-670) in Signal transducer and activator of transcription 5B (STAT5B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y436 on Growth hormone receptor (GHR)) of the Growth hormone receptor (GHR) LIG_SH2_III motif - Signal transducer and activator of transcription 5B (STAT5B) SH2 domain interaction

Context
References

(1) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
Yi et al. Mol. Endocrinol. (1996)




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