Description: Phosphorylation of Y288 and Y304 in the ITAM motif of Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).
Participants: (1) Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A) (2) Tyrosine-protein kinase SYK (SYK)
(1) Molecular mechanism of the Syk activation switch.Tsang et al. J. Biol. Chem. (2008)
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