Switch #:
SWTI000352
Switch type:
Avidity-sensing

Description:
Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).

Participants:
(1) High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(2) Tyrosine-protein kinase SYK (SYK)

Interactions
Interaction #1 FCER1G - SYK

Interfaces
(1) LIG_TYR_ITAM motif (62DGVYTGLSTRNQETYETL79) in High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(2) SH2 domain (15-92) in Tyrosine-protein kinase SYK (SYK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y65 and Y76 on High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)) of the High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) LIG_TYR_ITAM motif - Tyrosine-protein kinase SYK (SYK) SH2 domain interaction

Interaction #2 FCER1G - SYK

Interfaces
(3) LIG_TYR_ITAM motif (62DGVYTGLSTRNQETYETL79) in High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(4) SH2 domain (168-244) in Tyrosine-protein kinase SYK (SYK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y65 and Y76 on High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)) of the High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) LIG_TYR_ITAM motif - Tyrosine-protein kinase SYK (SYK) SH2 domain interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol
References

(1) Molecular mechanism of the Syk activation switch.
Tsang et al. J. Biol. Chem. (2008)




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