Description: Dephosphorylation of Y201 of Cytotoxic T-lymphocyte protein 4 (Ctla4) switches the specificity of Ctla4 from SH2 domain-containing proteins like Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11) to the AP-2 complex mu subunit (AP-2 complex subunit mu (Ap2m1)), thereby switching from inhibitory signal transmission and negative regulation of T cell responses to internalization and inactivation of Ctla4.
Participants: (1) Cytotoxic T-lymphocyte protein 4 (Ctla4) (2) AP-2 complex subunit mu (Ap2m1) (3) Tyrosine-protein phosphatase non-receptor type 11 (Ptpn11)
(1) Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.Shiratori et al. Immunity (1997)
