Switch #:
SWTI000247
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of the all-trans-retinoic acid ligand to the nuclear Retinoic acid receptor alpha (RARA) makes the binding site for the CORNRBOX motif of Nuclear receptor corepressor 1 (NCOR1) inaccessible.

Participants:
(1) Nuclear receptor corepressor 1 (NCOR1)
(2) Retinoic acid receptor alpha (RARA)

Interactions
Context
References

(1) A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
le Maire et al. Nat. Struct. Mol. Biol. (2010)




Loading visualisation