Switch #:
SWTI000246
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of the all-trans-retinoic acid ligand to the nuclear Retinoic acid receptor alpha (RARA) makes the binding site for the CORNRBOX motif of Nuclear receptor corepressor 1 (NCOR1) inaccessible.

Participants:
(1) Nuclear receptor corepressor 1 (NCOR1)
(2) Retinoic acid receptor alpha (RARA)

Interactions
Interaction #1 NCOR1 - RARA

Interfaces
(1) LIG_CORNRBOX motif (2051LADHICQII2059) in Nuclear receptor corepressor 1 (NCOR1)
(2) Ligand-binding domain of nuclear hormone receptor (207-406) in Retinoic acid receptor alpha (RARA)

Interaction Regulation
Effector binding Inhibition (all-trans-retinoic acid) of the Nuclear receptor corepressor 1 (NCOR1) LIG_CORNRBOX motif - Retinoic acid receptor alpha (RARA) Ligand-binding domain of nuclear hormone receptor interaction

Additional Information
Structural information: 3KMZ
Context
Switch localisation
Curated: nucleus
ELM curated: nucleus
Inferred: nuclear chromatin
References

(1) A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
le Maire et al. Nat. Struct. Mol. Biol. (2010)




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