Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Niemann-Pick C1 protein (NPC1) via an endocytosis motif.
Participants: (1) Niemann-Pick C1 protein (NPC1) (2) AP-2 complex subunit sigma (AP2S1)
(1) Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.Watari et al. Proc. Natl. Acad. Sci. U.S.A. (1999)
