Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of HLA class II histocompatibility antigen gamma chain (CD74) via an endocytosis motif.
Participants: (1) HLA class II histocompatibility antigen gamma chain (CD74) (2) AP-2 complex subunit sigma (AP2S1)
(1) Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain.Motta et al. J. Biol. Chem. (1995) (2) A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway.Pond et al. J. Biol. Chem. (1995)
Your browser does not support iframes.