Switch #:
SWTI000200
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T321 in the PDZ-binding motif of Voltage-dependent calcium channel gamma-2 subunit (Cacng2) by cAMP subfamily prevents binding to the PDZ domain of Disks large homolog 4 (Dlg4), an interaction involved in regulating synaptic targeting of AMPA-selective glutamate receptors.

Participants:
(1) Voltage-dependent calcium channel gamma-2 subunit (Cacng2)
(2) Disks large homolog 4 (Dlg4)

Interactions
Interaction #1 Cacng2 - Dlg4

Interfaces
(1) LIG_PDZ_Class_1 motif (318RRTTPV323) in Voltage-dependent calcium channel gamma-2 subunit (Cacng2)
(2) PDZ domain (Also known as DHR or GLGF) (160-244) in Disks large homolog 4 (Dlg4)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of T321 on Voltage-dependent calcium channel gamma-2 subunit (Cacng2)) of the Voltage-dependent calcium channel gamma-2 subunit (Cacng2) LIG_PDZ_Class_1 motif - Disks large homolog 4 (Dlg4) PDZ domain (Also known as DHR or GLGF) interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: T321: cAMP subfamily

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T321 : cAMP-dependent protein kinase catalytic subunit alpha (Prkaca).

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane
Inferred: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
References

(1) Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.
Choi et al. J. Biol. Chem. (2002)




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