Switch #:
SWTI000201
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T743 adjacent to the PTB-binding motif of Amyloid beta A4 protein (APP) reduces the affinity for Amyloid beta A4 precursor protein-binding family B member 1 (APBB1).

Participants:
(1) Amyloid beta A4 protein (APP)
(2) Amyloid beta A4 precursor protein-binding family B member 1 (APBB1)

Interactions
Interaction #1 APP - APBB1

Interfaces
(1) LIG_PTB_Apo_2 motif (756GYENPTYK763) in Amyloid beta A4 protein (APP)
(2) Phosphotyrosine interaction domain (PTB/PID) (543-664) in Amyloid beta A4 precursor protein-binding family B member 1 (APBB1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of T743 on Amyloid beta A4 protein (APP)) of the Amyloid beta A4 protein (APP) LIG_PTB_Apo_2 motif - Amyloid beta A4 precursor protein-binding family B member 1 (APBB1) Phosphotyrosine interaction domain (PTB/PID) interaction


Additional Information
Affinity : T743: 0.22 µM, pT743: 1.56 µM
Structural information: 3DXC, 3DXD, 3DXE
Context
References

(1) Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Radzimanowski et al. EMBO Rep. (2008)




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