Switch #:
SWTI000182
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S62 in the SH3-binding motif of Myc proto-oncogene protein (MYC) by GSK-3 subfamily disrupts its interaction with Myc box-dependent-interacting protein 1 (BIN1).

Participants:
(1) Myc proto-oncogene protein (MYC)
(2) Myc box-dependent-interacting protein 1 (BIN1)

Interactions
Interaction #1 MYC - BIN1

Interfaces
(1) LIG_SH3_2 motif (60PLSPSR65) in Myc proto-oncogene protein (MYC)
(2) Variant SH3 domain (524-590) in Myc box-dependent-interacting protein 1 (BIN1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S62 on Myc proto-oncogene protein (MYC)) of the Myc proto-oncogene protein (MYC) LIG_SH3_2 motif - Myc box-dependent-interacting protein 1 (BIN1) Variant SH3 domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S62: GSK-3 subfamily

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S62 : Cyclin-dependent kinase 5 (CDK5), Mitogen-activated protein kinase 3 (Mapk3), ERK2, Mitogen-activated protein kinase 8 (MAPK8), Mitogen-activated protein kinase 9 (MAPK9), Mitogen-activated protein kinase 10 (MAPK10), Serine/threonine-protein kinase mTOR (MTOR), Mitogen-activated protein kinase 1 (MAPK1).

Additional Information
Affinity : S62: 4.2 µM
Structural information: 1MV0
Context
Switch localisation
ELM curated: cytosol, focal adhesion, plasma membrane
Inferred: cytoplasm
References

(1) A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
Pineda-Lucena et al. J. Mol. Biol. (2005)




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