Switch #:
SWTI000183
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S160 adjacent to the NLS of Regulatory protein SWI6 (SWI6) decreases nuclear import of this protein by decreasing the affinity for Importin subunit alpha (SRP1).

Participants:
(1) Regulatory protein SWI6 (SWI6)
(2) Importin subunit alpha (SRP1)

Interactions
Interaction #1 SWI6 - SRP1

Interfaces
(1) TRG_NLS_MonoExtN_4 motif (161PLKKLKI167) in Regulatory protein SWI6 (SWI6)
(2) Armadillo/beta-catenin-like repeat (119-457) in Importin subunit alpha (SRP1)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of S160 on Regulatory protein SWI6 (SWI6)) of the Regulatory protein SWI6 (SWI6) TRG_NLS_MonoExtN_4 motif - Importin subunit alpha (SRP1) Armadillo/beta-catenin-like repeat interaction

Additional Information
Affinity : S160: 0.045 µM, S160E: 0.163 µM
Context
Switch localisation
Curated: cytosol
ELM curated: Nuclear pore, nucleus, NLS-dependent protein nuclear import complex
Inferred: cytoplasm
References

(1) Regulation of nuclear import by phosphorylation adjacent to nuclear localization signals.
Harreman et al. J. Biol. Chem. (2004)




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