Switch #:
SWTI000134
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1110 in the PTB-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Docking protein 1 (DOK1) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Docking protein 1 (DOK1)

Interactions
Interaction #1 EGFR - DOK1

Interfaces
(1) LIG_PTB_Phospho_1 motif (1104SVQNPVY1110) in Epidermal growth factor receptor (EGFR)
(2) PTB domain (IRS-1 type) (151-254) in Docking protein 1 (DOK1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1110 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_PTB_Phospho_1 motif - Docking protein 1 (DOK1) PTB domain (IRS-1 type) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1110 : Epidermal growth factor receptor (EGFR).

Context
Switch localisation
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
Inferred: perinuclear region of cytoplasm
References

(1) Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor.
Zhang et al. J. Mol. Biol. (2004)




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