Switch #:
SWTI000133
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T645 in the FHA-binding motif of Mediator of replication checkpoint protein 1 (mrc1) induces binding to the Serine/threonine-protein kinase cds1 (cds1) protein.

Participants:
(1) Mediator of replication checkpoint protein 1 (mrc1)
(2) Serine/threonine-protein kinase cds1 (cds1)

Interactions
Interaction #1 mrc1 - cds1

Interfaces
(1) LIG_FHA_2 motif (643VPTQLDS649) in Mediator of replication checkpoint protein 1 (mrc1)
(2) FHA domain (60-133) in Serine/threonine-protein kinase cds1 (cds1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T645 on Mediator of replication checkpoint protein 1 (mrc1)) of the Mediator of replication checkpoint protein 1 (mrc1) LIG_FHA_2 motif - Serine/threonine-protein kinase cds1 (cds1) FHA domain interaction

Context
Switch localisation
ELM curated: nucleus, Replication fork


Switch pathways
Inferred: Cell cycle
References

(1) Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.
Zhao et al. Mol. Cell. Biol. (2003)




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