Switch #:
SWTI000121
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S990 in the BRCT-binding motif of Fanconi anemia group J protein (BRIP1) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) Fanconi anemia group J protein (BRIP1)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

Interactions
Interaction #1 BRIP1 - BRCA1

Interfaces
(1) LIG_BRCT_BRCA1_1 motif (989TSPTF993) in Fanconi anemia group J protein (BRIP1)
(2) BRCA1 C Terminus (BRCT) domain (1648-1723) and (1756-1842) in Breast cancer type 1 susceptibility protein (BRCA1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S990 on Fanconi anemia group J protein (BRIP1)) of the Fanconi anemia group J protein (BRIP1) LIG_BRCT_BRCA1_1 motif - Breast cancer type 1 susceptibility protein (BRCA1) BRCA1 C Terminus (BRCT) domain interaction

Additional Information
Structural information: 1T15
Context
Switch localisation
ELM curated: nucleus, BRCA1-BARD1 complex


Switch pathways
Inferred: Fanconi anemia pathway
References

(1) The BRCT domain is a phospho-protein binding domain.
Yu et al. Science (2003)

(2) Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.
Clapperton et al. Nat. Struct. Mol. Biol. (2004)




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