Switch #:
SWTI000122
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S990 in the BRCT-binding motif of Fanconi anemia group J protein (BRIP1) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) Fanconi anemia group J protein (BRIP1)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

Interactions
Interaction #1 BRIP1 - BRCA1

Interfaces
(1) LIG_BRCT_BRCA1_2 motif (989TSPTFNK995) in Fanconi anemia group J protein (BRIP1)
(2) BRCA1 C Terminus (BRCT) domain (1648-1723) and (1756-1842) in Breast cancer type 1 susceptibility protein (BRCA1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S990 on Fanconi anemia group J protein (BRIP1)) of the Fanconi anemia group J protein (BRIP1) LIG_BRCT_BRCA1_2 motif - Breast cancer type 1 susceptibility protein (BRCA1) BRCA1 C Terminus (BRCT) domain interaction

Context
Switch localisation
ELM curated: nucleus, BRCA1-BARD1 complex


Switch pathways
Inferred: Fanconi anemia pathway
References

(1) The BRCT domain is a phospho-protein binding domain.
Yu et al. Science (2003)




Loading visualisation

↑