Description: Phosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).
Participants: (1) Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) (2) 14-3-3 protein zeta/delta (YWHAZ)
(1) Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.Zhang et al. Proc. Natl. Acad. Sci. U.S.A. (1999)
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