Switches.ELM

Switch #:

SWTI000107

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S775 by RAC-alpha serine/threonine-protein kinase (AKT1) in the 14-3-3-binding motif of Ataxin-1 (ATXN1) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.

Participants:
(1) Ataxin-1 (ATXN1)
(2) 14-3-3 protein zeta/delta (YWHAZ)

Interactions

Interaction #1 ATXN1 - YWHAZ

Interfaces
(1) LIG_14-3-3_1 motif (₇₇₂RRWSAP₇₇₇) in Ataxin-1 (ATXN1)
(2) 14-3-3 protein_(3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₇₇₅ on Ataxin-1 (ATXN1)) of the Ataxin-1 (ATXN1) LIG_14-3-3_1 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₇₇₅: RAC-alpha serine/threonine-protein kinase (AKT1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S₇₇₅ : RAC-alpha serine/threonine-protein kinase (AKT1), cAMP-dependent protein kinase catalytic subunit alpha (PRKACA).

Context

References

(1) Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Chen et al. Cell (2003)