Switch #:
SWTI000066
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S41 in the Pin1-binding motif of Protein X (X) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Protein X (X)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 X - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (38SSPSPS43) in Protein X (X)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S41 on Protein X (X)) of the Protein X (X) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.
Pang et al. Gastroenterology (2007)




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