Switch #:
SWTI000067
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S147 in the Pin1-binding motif of Protein BTG2 (BTG2) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Protein BTG2 (BTG2)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 BTG2 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (144GRSSPS149) in Protein BTG2 (BTG2)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S147 on Protein BTG2 (BTG2)) of the Protein BTG2 (BTG2) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.
Hong et al. J. Biol. Chem. (2005)




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