Description: Hydroxylation of P402 in the VHL-binding motif of Hypoxia-inducible factor 1-alpha (HIF1A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.
Participants: (1) Hypoxia-inducible factor 1-alpha (HIF1A) (2) Von Hippel-Lindau disease tumor suppressor (VHL)
(1) Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.Hon et al. Nature (2002) (2) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.Hirsilä et al. J. Biol. Chem. (2003)
